Real Madrid opened a two-point lead over Villarreal at the top of La Liga when Cristiano Ronaldo set a club scoring record in a 3-0 stroll at home to Levante on Saturday.
A second half double from Karim Benzema helped Real Madrid to a 4-1 victory at Girona on Sunday and maintain their perfect La Liga start in the post-Cristiano Ronaldo era.
Liverpool received a relatively kind draw for the group stage of this year's Champions League
Real went top with one game to play after thrashing Atletico Madrid 4-0 while rivals Sociedad slipped to a 3-2 defeat at Celta Vigo.
Here, Reuters Sport highlights five reasons why last season's double winners have collapsed.
Atletico Madrid coach Diego Simeone praised his team's spirit after knocking holders Barcelona out of the Champions League.
Striker Mariano's header was glanced onto the crossbar by Sociedad's Andoni Gorosabel while the loose ball fell to Marco Asensio, whose shot was deflected wide for a corner from which Raphael Varane header hit the top of the bar.
Cristiano Ronaldo answered his critics with a hat-trick as Real Madid came from behind to win 4-1 at Alaves and provisionally go three points clear at the top of La Liga.
In a big blow to Real Madrid's title hopes, Real Betis held them to a goalless draw in their La Liga encounter on Sunday.
Spain goalkeeper Iker Casillas left Real Madrid on Saturday after 16 seasons as an iconic figure at the Bernabeu.
For months, the 2024 Ballon d'Or seemed to have a clear front-runner, with everyone anticipating the coronation of Vinícius Júnior as the new king of football.
Real Madrid's Javier Hernandez struck twice as they came from behind to beat Celta Vigo 4-2 away and keep the pressure on Barcelona at the top of La Liga on Sunday.
Real Madrid's stuttering season continued as they were reduced to 10 men and then slumped to an 11th La Liga defeat of the campaign by going down 3-1 at Real Sociedad.
The three Premier League and three La Liga clubs in the last eight avoided each other, with Manchester City up against Atletico Madrid and Liverpool to face Portuguese side Benfica.
IMAGES from the Champions League matches played on Wednesday.
'This was why Juventus brought me here. To help do things that they have never done before'
La Liga champions Barcelona stayed on the heels of leaders Real Madrid by coasting to a 3-0 home win over Athletic Bilbao on Saturday as Lionel Messi became the club's top scorer from free kicks.
Chelsea's Champions League semi-final defeat by Atletico Madrid hinged on a pivotal second-half minute and the expertise of a young goalkeeper on loan from the Premier League club to the Spanish side, Jose Mourinho said on Wednesday.
Atletico Madrid delayed Barcelona's La Liga title celebrations by beating Valencia 3-2 at home in an entertaining game on Wednesday at a sparsely attended Wanda Metropolitano stadium.
Real were smarting from a surprise 1-1 draw at struggling Elche in their last match and were missing captain Sergio Ramos, who was out with a stomach bug.
Real Madrid captain Sergio Ramos performed another rescue act to wreck Napoli's brave comeback attempt and take the Champions League title-holders into the quarter-finals.
All the action from La Liga and Serie A matches played on Sunday.
Holders Bayern Munich and nine-times winners Real Madrid will face each other in a mouthwatering Champions League semi-final this month with Atletico Madrid up against Chelsea.
Real Madrid paid more than 200 million euros ($227.76 million) to assemble their forward line of Cristiano Ronaldo, Gareth Bale and Karim Benzema, but the attacking trio failed them again in Wednesday's Champions League exit to Juventus.
There were a few nerves at the end but Liverpool set up a Champions League semi-final with Spain's Villarreal after Roberto Firmino scored twice in a 3-3 second-leg draw with Benfica on Wednesday to ensure a 6-4 aggregate win.
'I expect a brave Napoli that plays from the back and presses high, that doesn't speculate, has a lot of individual talent, it's a big game and it's a great team, current champions of Italy.'
Real Madrid star Vinicius racially attacked for 10th time this season.
Atletico Madrid were handed a chance to avenge last season's Champions League final defeat by city rivals and record 10-times winners Real after the two sides were drawn together in the last eight on Friday. Paris St Germain and Barcelona were paired together having met in the group stage, with the French side winning in Paris and the Catalans coming out on top in Spain.
Lionel Messi's double strike helped Barcelona scrape a 3-2 victory over Real Sociedad on Saturday to keep the pressure on La Liga leaders Real Madrid, who needed a brace from Isco to beat Sporting Gijon by the same scoreline.
Diego Costa's season is getting better and better. The Atletico striker found the net again and took the Madrid team atop the La Liga table.
Cristiano Ronaldo and Lionel Messi will resume their perennial battle to be crowned the world's best footballer after they headed the shortlist of 30 players for the 2016 Ballon d'Or announced on Monday.
In his absence, the league champions have made a lacklustre start to the season, losing their opening game to Athletic Bilbao before taking just four points from fixtures against Real Betis and Osasuna.
News of all that's transpired on and off the football field
Real Madrid were the big winners in Spain as their success at Almeria was followed by a Barcelona draw and a surprise Atletico Madrid defeat.
A Neymar double, a spectacular volley from Luis Suarez and a goal for Lionel Messi saw top of the table Barcelona's unstoppable strike force sweep aside Real Sociedad 4-0 in La Liga on Saturday.
Holders Manchester City will take on RB Leipzig, Red Star Belgrade and Young Boys in Group G.
Exactly four months after succeeding Rafael Benitez and inheriting a Real Madrid side on the brink of institutional crisis, Zinedine Zidane completed the team's revival by guiding them past Manchester City to the Champions League final.
Real Madrid president Florentino Perez has blamed Manchester United's "lack of negotiating experience" for the failure of goalkeeper David De Gea's move to the Spanish capital on Monday.
News of all that's transpired on and off the football field
Morata to stay on loan at Juventus for another season